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Prognostic Factors for Long-Term Survival in Patients with Ampullary Carcinoma : The Results of a 15-Year Observation Period after Pancreaticoduodenectomy
Joint Authors
Jacob, Dietmar
Gül, Safak
Guckelberger, Olaf
Krannich, Alexander
Bahra, Marcus
Pelzer, Uwe
Puhl, Gero
Andreou, Andreas
Klein, Fritz
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Although ampullary carcinoma has the best prognosis among all periampullary carcinomas, its long-term survival remains low.
Prognostic factors are only available for a period of 10 years after pancreaticoduodenectomy.
The aim of this retrospective study was to identify factors that influence the long-term patient survival over a 15-year observation period.
Methods.
From 1992 to 2007, 143 patients with ampullary carcinoma underwent pancreatic resection.
86 patients underwent pylorus-preserving pancreaticoduodenectomy (60%) and 57 patients underwent standard Kausch-Whipple pancreaticoduodenectomy (40%).
Results.
The overall 1-, 5-, 10-, and 15-year survival rates were 79%, 40%, 24%, and 10%, respectively.
Within a mean observation period of 30 (0–205) months, 100 (69%) patients died.
Survival analysis showed that positive lymph node involvement P=0.001, lymphatic vessel invasion P=0.0001, intraoperative administration of packed red blood cells P=0.03, an elevated CA 19-9 P=0.03, jaundice P=0.04, and an impaired patient condition P=0.01 are strong negative predictors for a reduced patient survival.
Conclusions.
Patients with ampullary carcinoma have distinctly better long-term survival than patients with pancreatic adenocarcinoma.
Long-term survival depends strongly on lymphatic nodal and vessel involvement.
Moreover, a preoperative elevated CA 19-9 proved to be a significant prognostic factor.
Adjuvant therapy may be essential in patients with this risk constellation.
American Psychological Association (APA)
Klein, Fritz& Jacob, Dietmar& Bahra, Marcus& Pelzer, Uwe& Puhl, Gero& Krannich, Alexander…[et al.]. 2014. Prognostic Factors for Long-Term Survival in Patients with Ampullary Carcinoma : The Results of a 15-Year Observation Period after Pancreaticoduodenectomy. HPB Surgery،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-512330
Modern Language Association (MLA)
Klein, Fritz…[et al.]. Prognostic Factors for Long-Term Survival in Patients with Ampullary Carcinoma : The Results of a 15-Year Observation Period after Pancreaticoduodenectomy. HPB Surgery No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-512330
American Medical Association (AMA)
Klein, Fritz& Jacob, Dietmar& Bahra, Marcus& Pelzer, Uwe& Puhl, Gero& Krannich, Alexander…[et al.]. Prognostic Factors for Long-Term Survival in Patients with Ampullary Carcinoma : The Results of a 15-Year Observation Period after Pancreaticoduodenectomy. HPB Surgery. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-512330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512330