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The Role of PPARs in Placental Immunology : A Systematic Review of the Literature
Joint Authors
Hutter, Stefan
Andergassen, Ulrich
Knabl, Julia
Jeschke, Udo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Pregnancy is a state of immunotolerance, and pregnancy outcome is strongly linked to the correct activation and balancing of the maternal immune system.
Besides abortion as possible result of improper early pregnancy development, other pregnancy associated conditions like preeclampsia (PE), intrauterine growth retardation (IUGR), preterm labour, or gestational diabetes mellitus (GDM) are linked to immunologic overactivation and dysregulation.
Both the innate and the adaptive immune system, and therefore B and T lymphocytes, natural killer cells (NK), macrophages and dendritic cells (DCs) are all involved in trophoblast invasion, pregnancy maintenance, and development of pregnancy disorders.
Peroxisome proliferator activated receptors (PPARs) are nuclear transcription factors with three known isotypes: PPARα, PPARβ/δ, and PPARγ.
They are expressed in most human organs and their function extends from regulating metabolism, homeostasis, and carcinogenesis to immune response.
In the recent years, PPARs have been identified in most reproductive tissues and in all lines of immune cells.
Only in few cases, the role of PPARs in reproductive immunology has been elucidated though the role of PPARs in immune answer and immunotolerance is evident.
Within this paper we would like to give an update on today’s knowledge about PPARs and immune cells in reproduction and highlight interesting interferences in regard of future therapeutic targets.
American Psychological Association (APA)
Hutter, Stefan& Knabl, Julia& Andergassen, Ulrich& Jeschke, Udo. 2013. The Role of PPARs in Placental Immunology : A Systematic Review of the Literature. PPAR Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512333
Modern Language Association (MLA)
Hutter, Stefan…[et al.]. The Role of PPARs in Placental Immunology : A Systematic Review of the Literature. PPAR Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-512333
American Medical Association (AMA)
Hutter, Stefan& Knabl, Julia& Andergassen, Ulrich& Jeschke, Udo. The Role of PPARs in Placental Immunology : A Systematic Review of the Literature. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512333