Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells
Joint Authors
Zhuo, Min
Zhou, Jinghui
Zhang, Yu
Meng, Yuhuan
Du, Hongli
Ling, Fei
Wang, Xiaoning
Chen, Junhui
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Type 2 Diabetes Mellitus (T2DM) and obesity have become increasingly prevalent in recent years.
Recent studies have focused on identifying causal variations or candidate genes for obesity and T2DM via analysis of expression quantitative trait loci (eQTL) within a single tissue.
T2DM and obesity are affected by comprehensive sets of genes in multiple tissues.
In the current study, gene expression levels in multiple human tissues from GEO datasets were analyzed, and 21 candidate genes displaying high percentages of differential expression were filtered out.
Specifically, DENND1B, LYN, MRPL30, POC1B, PRKCB, RP4-655J12.3, HIBADH, and TMBIM4 were identified from the T2DM-control study, and BCAT1, BMP2K, CSRNP2, MYNN, NCKAP5L, SAP30BP, SLC35B4, SP1, BAP1, GRB14, HSP90AB1, ITGA5, and TOMM5 were identified from the obesity-control study.
The majority of these genes are known to be involved in T2DM and obesity.
Therefore, analysis of gene expression in various tissues using GEO datasets may be an effective and feasible method to determine novel or causal genes associated with T2DM and obesity.
American Psychological Association (APA)
Chen, Junhui& Meng, Yuhuan& Zhou, Jinghui& Zhuo, Min& Ling, Fei& Zhang, Yu…[et al.]. 2013. Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-512346
Modern Language Association (MLA)
Chen, Junhui…[et al.]. Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells. Journal of Diabetes Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-512346
American Medical Association (AMA)
Chen, Junhui& Meng, Yuhuan& Zhou, Jinghui& Zhuo, Min& Ling, Fei& Zhang, Yu…[et al.]. Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-512346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512346