Naja naja karachiensis Envenomation : Biochemical Parameters for Cardiac, Liver, and Renal Damage along with Their Neutralization by Medicinal Plants
Joint Authors
Sajjad, Ashif
Asad, Muhammad Hassham Hassan Bin
Karim, Sabiha
Mehmood, Zahid
Hussain, Izhar
Ansari, Muhammad Muzzmil
Mahmood, Qaisar
Durr-e-Sabih,
Murtaza, Ghulam
Mehmood, Rubada
Ubaid, Muhammad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Naja naja karachiensis envenomation was found to hit more drastically heart, liver, and kidneys.
400 μg/kg of venom-raised moderate serum levels of ALT (72±4.70 U/L, 0.1>P>0.05), AST (157±24.24 U/L, 0.1>P>0.05), urea (42±3.08 mg/dL, 0.05>P>0.02), creatinine (1.74±0.03 mg/dL, 0.01>P>0.001), CK-MB (21±1.5 U/L, 0.05>P>0.02), and LDH (2064±15.98 U/L, P<0.001) were injected in experimental rabbits.
However, lethality was enhanced with 800 μg/kg of venom in terms of significant release of ALT (86±5.0 U/L, 0.05>P>0.02), AST (251±18.2 U/L, 0.01>P>0.001), urea (57.6±3.84 mg/dL, 0.02>P>0.01), creatinine (2.1±0.10 mg/dL, 0.02>P>0.01), CK-MB (77±11.22 U/L, 0.05>P>0.02), and LDH (2562±25.14 U/L, P≪0.001).
Among twenty-eight tested medicinal plant extracts, only Stenolobium stans (L.) Seem was found the best antivenom (P>0.5) compared to the efficacy of standard antidote (ALT =52.5±3.51 U/L, AST =69.5±18.55 U/L, urea =31.5±0.50 mg/dL, creatinine =1.08±0.02 mg/dL, CK-MB =09±0.85 U/L, and LDH =763±6.01 U/L).
Other plant extracts were proved less beneficial and partly neutralized the toxicities posed by cobra venom.
However, it is essential in future to isolate and characterize bioactive compound(s) from Stenolobium stans (L.) Seem extract to overcome the complications of snake bite.
American Psychological Association (APA)
Asad, Muhammad Hassham Hassan Bin& Murtaza, Ghulam& Ubaid, Muhammad& Durr-e-Sabih, & Sajjad, Ashif& Mehmood, Rubada…[et al.]. 2014. Naja naja karachiensis Envenomation : Biochemical Parameters for Cardiac, Liver, and Renal Damage along with Their Neutralization by Medicinal Plants. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-512362
Modern Language Association (MLA)
Asad, Muhammad Hassham Hassan Bin…[et al.]. Naja naja karachiensis Envenomation : Biochemical Parameters for Cardiac, Liver, and Renal Damage along with Their Neutralization by Medicinal Plants. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-512362
American Medical Association (AMA)
Asad, Muhammad Hassham Hassan Bin& Murtaza, Ghulam& Ubaid, Muhammad& Durr-e-Sabih, & Sajjad, Ashif& Mehmood, Rubada…[et al.]. Naja naja karachiensis Envenomation : Biochemical Parameters for Cardiac, Liver, and Renal Damage along with Their Neutralization by Medicinal Plants. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-512362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512362