Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma
Joint Authors
Wang, Shuai
Liang, Zhaohui
Geng, Shaomei
Ma, Shucheng
Jiao, Baohua
Lu, Shengkui
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To investigate the clinical significance of microRNA-17 (miR-17) expression in human gliomas.
Methods.
Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression patterns of miR-17 in 108 glioma and 20 normal brain tissues.
The associations of miR-17 expression with clinicopathological factors and prognosis of glioma patients were also statistically analyzed.
Results.
Compared with normal brain tissues, miR-17 expression was significantly higher in glioma tissues (P<0.001).
In addition, the increased expression of miR-17 in glioma was significantly associated with advanced pathological grade (P=0.006) and low Karnofsky performance score (KPS, P=0.01).
Moreover, Kaplan-Meier survival and Cox regression analyses showed that miR-17 overexpression (P=0.008) and advanced pathological grade (P=0.02) were independent factors predicting poor prognosis for gliomas.
Furthermore, subgroup analyses showed that miR-17 expression was significantly associated with poor overall survival in glioma patients with high pathological grades (for grade III~IV: P<0.001).
Conclusions.
Our data offer the convinced evidence that the increased expression of miR-17 may have potential value for predicting poor prognosis in glioma patients with high pathological grades, indicating that miR-17 may contribute to glioma progression and be a candidate therapeutic target for this disease.
American Psychological Association (APA)
Lu, Shengkui& Wang, Shuai& Geng, Shaomei& Ma, Shucheng& Liang, Zhaohui& Jiao, Baohua. 2012. Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-512386
Modern Language Association (MLA)
Lu, Shengkui…[et al.]. Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-512386
American Medical Association (AMA)
Lu, Shengkui& Wang, Shuai& Geng, Shaomei& Ma, Shucheng& Liang, Zhaohui& Jiao, Baohua. Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-512386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512386