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Control of V(D)J Recombination through Transcriptional Elongation and Changes in Locus Chromatin Structure and Nuclear Organization
Joint Authors
Hernández-Munain, Cristina
García-Mariscal, Alberto
García, Vanina
del Blanco, Beatriz
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
V(D)J recombination is the assembly of gene segments at the antigen receptor loci to generate antigen receptor diversity in T and B lymphocytes.
This process is regulated, according to defined developmental programs, by the action of a single specific recombinase complex formed by the recombination antigen gene (RAG-1/2) proteins that are expressed in immature lymphocytes.
V(D)J recombination is strictly controlled by RAG-1/2 accessibility to specific recombination signal sequences in chromatin at several levels: cellular lineage, temporal regulation, gene segment order, and allelic exclusion.
DNA cleavage by RAG-1/2 is regulated by the chromatin structure, transcriptional elongation, and three-dimensional architecture and position of the antigen receptor loci in the nucleus.
Cis-elements specifically direct transcription and V(D)J recombination at these loci through interactions with transacting factors that form molecular machines that mediate a sequence of structural events.
These events open chromatin to activate transcriptional elongation and to permit the access of RAG-1/2 to their recombination signal sequences to drive the juxtaposition of the V, D, and J segments and the recombination reaction itself.
This chapter summarizes the advances in this area and the important role of the structure and position of antigen receptor loci within the nucleus to control this process.
American Psychological Association (APA)
del Blanco, Beatriz& García, Vanina& García-Mariscal, Alberto& Hernández-Munain, Cristina. 2011. Control of V(D)J Recombination through Transcriptional Elongation and Changes in Locus Chromatin Structure and Nuclear Organization. Genetics Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-512415
Modern Language Association (MLA)
del Blanco, Beatriz…[et al.]. Control of V(D)J Recombination through Transcriptional Elongation and Changes in Locus Chromatin Structure and Nuclear Organization. Genetics Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-512415
American Medical Association (AMA)
del Blanco, Beatriz& García, Vanina& García-Mariscal, Alberto& Hernández-Munain, Cristina. Control of V(D)J Recombination through Transcriptional Elongation and Changes in Locus Chromatin Structure and Nuclear Organization. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-512415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512415