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Drosophila Models of Tauopathies : What Have We Learned?
Joint Authors
Callaerts, Patrick
Lambert, Jean-Charles
Dermaut, Bart
Gistelinck, Marc
Dourlen, Pierre
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aggregates of the microtubule-associated protein Tau are neuropathological hallmark lesions in Alzheimer's disease (AD) and related primary tauopathies.
In addition, Tau is genetically implicated in a number of human neurodegenerative disorders including frontotemporal dementia (FTD) and Parkinson's disease (PD).
The exact mechanism by which Tau exerts its neurotoxicity is incompletely understood.
Here, we give an overview of how studies using the genetic model organism Drosophila over the past decade have contributed to the molecular understanding of Tau neurotoxicity.
We compare the different available readouts for Tau neurotoxicity in flies and review the molecular pathways in which Tau has been implicated.
Finally, we emphasize that the integration of genome-wide approaches in human or mice with high-throughput genetic validation in Drosophila is a fruitful approach.
American Psychological Association (APA)
Gistelinck, Marc& Lambert, Jean-Charles& Callaerts, Patrick& Dermaut, Bart& Dourlen, Pierre. 2012. Drosophila Models of Tauopathies : What Have We Learned?. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-512419
Modern Language Association (MLA)
Gistelinck, Marc…[et al.]. Drosophila Models of Tauopathies : What Have We Learned?. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-512419
American Medical Association (AMA)
Gistelinck, Marc& Lambert, Jean-Charles& Callaerts, Patrick& Dermaut, Bart& Dourlen, Pierre. Drosophila Models of Tauopathies : What Have We Learned?. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-512419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512419