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The Role of Zinc in Alzheimer's Disease
Joint Authors
Whitehouse, Isobel J.
Watt, Nicole T.
Hooper, Nigel M.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Zinc, the most abundant trace metal in the brain, has numerous functions, both in health and in disease.
Zinc is released into the synaptic cleft of glutamatergic neurons alongside glutamate from where it interacts and modulates NMDA and AMPA receptors.
In addition, zinc has multifactorial functions in Alzheimer's disease (AD).
Zinc is critical in the enzymatic nonamyloidogenic processing of the amyloid precursor protein (APP) and in the enzymatic degradation of the amyloid-β (Aβ) peptide.
Zinc binds to Aβ promoting its aggregation into neurotoxic species, and disruption of zinc homeostasis in the brain results in synaptic and memory deficits.
Thus, zinc dyshomeostasis may have a critical role to play in the pathogenesis of AD, and the chelation of zinc is a potential therapeutic approach.
American Psychological Association (APA)
Watt, Nicole T.& Whitehouse, Isobel J.& Hooper, Nigel M.. 2010. The Role of Zinc in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-512422
Modern Language Association (MLA)
Watt, Nicole T.…[et al.]. The Role of Zinc in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-512422
American Medical Association (AMA)
Watt, Nicole T.& Whitehouse, Isobel J.& Hooper, Nigel M.. The Role of Zinc in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-512422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512422