Hypothyroidism in Noninterferon Treated-HCV Infected Individuals Is Associated with Abnormalities in the Regulation of Th17 Cells
Joint Authors
Garcia-Samper, Xóchitl
Salazar, Luis A.
Fortoul, Teresa I.
Masso, Felipe A.
Jimenez-Martinez, M. Carmen
Rendón-Huerta, Erika P.
Suarez-Carpio, Rafael
Montaño, Luis F.
Source
Hepatitis Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
HCV-Ag-specific TH17 cells secrete IL17, a cytokine involved in autoimmune diseases and regulated by IL10 and TGF-b.
5–12% of patients with chronic HCV infection have hypothyroidism.
We evaluated the role of these cytokines in this patients by determining serum concentration of TsH, T3, free T4, IL2, IL10, IL12, IL17, TGF-b, anti-TG, TPO, CCP, GBM, and cardiolipin antibodies in 87 chronically noninterferon treated HCV-infected patients.
20 patients (group A) had elevated TsH values (>5 μUI/ml) whereas the remaining 67 (group B) had normal values.
The percentage of anti-TPO, TG, GBM, and cardiolipin antibodies in group A patients (33%, 41%, 5% and 5%, resp.) as well as IL17, IL2 and TGF-b concentrations (25±23 pg/ml, 643±572 pg/ml, and 618±221 pg/ml, resp.) were significantly higher than group B.
Abnormal Th17 regulation mediated by IL-2 and low TGF-b concentrations is associated with hypothyroidism in chronically-infected HCV patients.
American Psychological Association (APA)
Salazar, Luis A.& Garcia-Samper, Xóchitl& Suarez-Carpio, Rafael& Jimenez-Martinez, M. Carmen& Rendón-Huerta, Erika P.& Masso, Felipe A.…[et al.]. 2010. Hypothyroidism in Noninterferon Treated-HCV Infected Individuals Is Associated with Abnormalities in the Regulation of Th17 Cells. Hepatitis Research and Treatment،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-512427
Modern Language Association (MLA)
Salazar, Luis A.…[et al.]. Hypothyroidism in Noninterferon Treated-HCV Infected Individuals Is Associated with Abnormalities in the Regulation of Th17 Cells. Hepatitis Research and Treatment No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-512427
American Medical Association (AMA)
Salazar, Luis A.& Garcia-Samper, Xóchitl& Suarez-Carpio, Rafael& Jimenez-Martinez, M. Carmen& Rendón-Huerta, Erika P.& Masso, Felipe A.…[et al.]. Hypothyroidism in Noninterferon Treated-HCV Infected Individuals Is Associated with Abnormalities in the Regulation of Th17 Cells. Hepatitis Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-512427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512427