Intoxication by Intraperitoneal Injection or Oral Gavage Equally Potentiates Postburn Organ Damage and Inflammation
Joint Authors
Chen, Michael M.
Choudhry, Mashkoor A.
Curtis, Brenda J.
Kovacs, Elizabeth J.
Palmer, Jessica L.
Ippolito, Jill A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The increasing prevalence of binge drinking and its association with trauma necessitate accurate animal models to examine the impact of intoxication on the response and outcome to injuries such as burn.
While much research has focused on the effect of alcohol dose and duration on the subsequent inflammatory parameters following burn, little evidence exists on the effect of the route of alcohol administration.
We examined the degree to which intoxication before burn injury causes systemic inflammation when ethanol is given by intraperitoneal (i.p.) injection or oral gavage.
We found that intoxication potentiates postburn damage in the ileum, liver, and lungs of mice to an equivalent extent when either ethanol administration route is used.
We also found a similar hematologic response and levels of circulating interleukin-6 (IL-6) when either ethanol paradigm achieved intoxication before burn.
Furthermore, both i.p.
and gavage resulted in similar blood alcohol concentrations at all time points tested.
Overall, our data show an equal inflammatory response to burn injury when intoxication is achieved by either i.p.
injection or oral gavage, suggesting that findings from studies using either ethanol paradigm are directly comparable.
American Psychological Association (APA)
Chen, Michael M.& Palmer, Jessica L.& Ippolito, Jill A.& Curtis, Brenda J.& Choudhry, Mashkoor A.& Kovacs, Elizabeth J.. 2013. Intoxication by Intraperitoneal Injection or Oral Gavage Equally Potentiates Postburn Organ Damage and Inflammation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-512459
Modern Language Association (MLA)
Chen, Michael M.…[et al.]. Intoxication by Intraperitoneal Injection or Oral Gavage Equally Potentiates Postburn Organ Damage and Inflammation. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-512459
American Medical Association (AMA)
Chen, Michael M.& Palmer, Jessica L.& Ippolito, Jill A.& Curtis, Brenda J.& Choudhry, Mashkoor A.& Kovacs, Elizabeth J.. Intoxication by Intraperitoneal Injection or Oral Gavage Equally Potentiates Postburn Organ Damage and Inflammation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-512459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512459