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Infection of Human Coronary Artery Endothelial Cells by Group B Streptococcus Contributes to Dysregulation of Apoptosis, Hemostasis, and Innate Immune Responses
Joint Authors
Kneitz, Susanne
Kobsar, Anna
Löffler, Jürgen
Beyrich, Claudia
Speer, Christian P.
Eigenthaler, Martin
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Early onset sepsis due to group B streptococcus leads to neonatal morbidity, increased mortality, and long-term neurological deficencies.
Interaction between septicemic GBS and confluent monolayers of human coronary artery endothelial cells (HCAECs) was analyzed by genome wide expression profiling.
In total, 124 genes were differentially expressed (89 upregulated, 35 downregulated) based on a more than 3-fold difference to control HCAEC.
Regulated genes are involved in apoptosis, hemostasis, oxidative stress response, infection, and inflammation.
Regulation of selected genes and proteins identified in the gene array analysis was confirmed by Real-time RT-PCR assay (granulocyte chemotactic protein 2), ELISA (urokinase, cyclooxygenase 2, granulocyte chemotactic protein 1), and western blotting (Heme oxygenase1, BCL2 interacting protein) at various time points between 4 and 24 hours.
These results indicate that GBS infection might influence signalling pathways leading to impaired function of the innate immune system and hemorrhagic and inflammatory complications during GBS sepsis.
American Psychological Association (APA)
Beyrich, Claudia& Löffler, Jürgen& Kobsar, Anna& Speer, Christian P.& Kneitz, Susanne& Eigenthaler, Martin. 2011. Infection of Human Coronary Artery Endothelial Cells by Group B Streptococcus Contributes to Dysregulation of Apoptosis, Hemostasis, and Innate Immune Responses. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-512462
Modern Language Association (MLA)
Beyrich, Claudia…[et al.]. Infection of Human Coronary Artery Endothelial Cells by Group B Streptococcus Contributes to Dysregulation of Apoptosis, Hemostasis, and Innate Immune Responses. Mediators of Inflammation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-512462
American Medical Association (AMA)
Beyrich, Claudia& Löffler, Jürgen& Kobsar, Anna& Speer, Christian P.& Kneitz, Susanne& Eigenthaler, Martin. Infection of Human Coronary Artery Endothelial Cells by Group B Streptococcus Contributes to Dysregulation of Apoptosis, Hemostasis, and Innate Immune Responses. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-512462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512462