Vascular Homeostasis and Angiogenesis Determine Therapeutic Effectiveness in Type 2 Diabetes
Joint Authors
Futrakul, Narisa
Futrakul, Prasit
Source
International Journal of Vascular Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Under common practice, recognition and treatment of type 2 diabetic nephropathy (DN) are usually revealed at a rather late stage (CKD stages 3–5) due to the insensitiveness of available diagnostic markers.
Accumulating data obtained from vascular homeostasis in late stage DN demonstrated (1) a defective angiogenesis and impaired NO production which explains the therapeutic resistance to vasodilators and the inability to correct chronic renal ischemia and (2) an abnormally elevated antiangiogenesis and a progressive vascular disease which correlates with the altered renal hemodynamics characterized by a progressive reduction in renal perfusion as the disease severity progressed.
In contract, the vascular homeostasis is adequately functional in early stage DN.
Thus, vasodilator treatment at early stage DN (CKD stages 1-2) can enhance renal perfusion, correct the renal ischemia, and restore renal function.
American Psychological Association (APA)
Futrakul, Narisa& Futrakul, Prasit. 2011. Vascular Homeostasis and Angiogenesis Determine Therapeutic Effectiveness in Type 2 Diabetes. International Journal of Vascular Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-512464
Modern Language Association (MLA)
Futrakul, Narisa& Futrakul, Prasit. Vascular Homeostasis and Angiogenesis Determine Therapeutic Effectiveness in Type 2 Diabetes. International Journal of Vascular Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-512464
American Medical Association (AMA)
Futrakul, Narisa& Futrakul, Prasit. Vascular Homeostasis and Angiogenesis Determine Therapeutic Effectiveness in Type 2 Diabetes. International Journal of Vascular Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-512464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512464