Low-Density Lipoprotein Modified by Myeloperoxidase in Inflammatory Pathways and Clinical Studies
Joint Authors
Delporte, Cédric
Vanhamme, Luc
Roumeguère, Thierry
Van Antwerpen, Pierre
Zouaoui Boudjeltia, Karim
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-24
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Oxidation of low-density lipoprotein (LDL) has a key role in atherogenesis.
Among the different models of oxidation that have been studied, the one using myeloperoxidase (MPO) is thought to be more physiopathologically relevant.
Apolipoprotein B-100 is the unique protein of LDL and is the major target of MPO.
Furthermore, MPO rapidly adsorbs at the surface of LDL, promoting oxidation of amino acid residues and formation of oxidized lipoproteins that are commonly named Mox-LDL.
The latter is not recognized by the LDL receptor and is accumulated by macrophages.
In the context of atherogenesis, Mox-LDL accumulates in macrophages leading to foam cell formation.
Furthermore, Mox-LDL seems to have specific effects and triggers inflammation.
Indeed, those oxidized lipoproteins activate endothelial cells and monocytes/macrophages and induce proinflammatory molecules such as TNFα and IL-8.
Mox-LDL may also inhibit fibrinolysis mediated via endothelial cells and consecutively increase the risk of thrombus formation.
Finally, Mox-LDL has been involved in the physiopathology of several diseases linked to atherosclerosis such as kidney failure and consequent hemodialysis therapy, erectile dysfunction, and sleep restriction.
All these issues show that the investigations of MPO-dependent LDL oxidation are of importance to better understand the inflammatory context of atherosclerosis.
American Psychological Association (APA)
Delporte, Cédric& Van Antwerpen, Pierre& Vanhamme, Luc& Roumeguère, Thierry& Zouaoui Boudjeltia, Karim. 2013. Low-Density Lipoprotein Modified by Myeloperoxidase in Inflammatory Pathways and Clinical Studies. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-512468
Modern Language Association (MLA)
Delporte, Cédric…[et al.]. Low-Density Lipoprotein Modified by Myeloperoxidase in Inflammatory Pathways and Clinical Studies. Mediators of Inflammation No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-512468
American Medical Association (AMA)
Delporte, Cédric& Van Antwerpen, Pierre& Vanhamme, Luc& Roumeguère, Thierry& Zouaoui Boudjeltia, Karim. Low-Density Lipoprotein Modified by Myeloperoxidase in Inflammatory Pathways and Clinical Studies. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-512468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512468