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Cell Therapies for Heart Function Recovery : Focus on Myocardial Tissue Engineering and Nanotechnologies
Joint Authors
Giraud, Marie-Noëlle
Guex, Anne Géraldine
Tevaearai, Hendrik T.
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cell therapies have gained increasing interest and developed in several approaches related to the treatment of damaged myocardium.
The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells.
It has, however, been postulated that the efficiency of injected cells could possibly be hindered by the mechanical trauma due to the injection and their low survival in the hostile environment.
It has indeed been demonstrated that cell mortality due to the injection approaches 90%.
Major issues still need to be resolved and bed-to-bench followup is paramount to foster clinical implementations.
The tissue engineering approach thus constitutes an attractive alternative since it provides the opportunity to deliver a large number of cells that are already organized in an extracellular matrix.
Recent laboratory reports confirmed the interest of this approach and already encouraged a few groups to investigate it in clinical studies.
We discuss current knowledge regarding engineered tissue for myocardial repair or replacement and in particular the recent implementation of nanotechnological approaches.
American Psychological Association (APA)
Giraud, Marie-Noëlle& Guex, Anne Géraldine& Tevaearai, Hendrik T.. 2012. Cell Therapies for Heart Function Recovery : Focus on Myocardial Tissue Engineering and Nanotechnologies. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-512472
Modern Language Association (MLA)
Giraud, Marie-Noëlle…[et al.]. Cell Therapies for Heart Function Recovery : Focus on Myocardial Tissue Engineering and Nanotechnologies. Cardiology Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-512472
American Medical Association (AMA)
Giraud, Marie-Noëlle& Guex, Anne Géraldine& Tevaearai, Hendrik T.. Cell Therapies for Heart Function Recovery : Focus on Myocardial Tissue Engineering and Nanotechnologies. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-512472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512472