Metabolic Alterations of the Zebrafish Brain after Acute Alcohol Treatment by 1H Nuclear Magnetic Resonance Spectroscopy
Joint Authors
Choi, Chi-Bong
Kim, Goo-Young
Lee, Do-Wan
Kim, Hyun-Ju
Bang, Eunjung
Woo, Dong-Cheol
Seoung, Youl-Hun
Choe, Bo-Young
Rhim, Hyang-Shuk
Kim, Sang-Young
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The purpose of this study is to investigate the metabolic alterations associated with acute alcohol treatment in zebrafish by 1H nuclear magnetic resonance spectroscopy (NMRS).
The brain metabolism of zebrafish was investigated after acute alcohol treatment (one-hour long exposure of adult fish to 0.00%, 0.25%, 0.50%, or 1.00% ethyl alcohol) with whole brain extraction.
The results of this study showed that glutamate (Glu) was significantly decreased, scyllo-inositol (sIns) showed a small apparent increase only in the highest acute treatment dose group, and myoinositol (mIns) showed a significant decrease.
[Glu]/[tCr] and [mIns]/[tCr] levels were significantly reduced regardless of the alcohol dose, and [sIns]/[tCr] was increased in the highest alcohol treatment dose group.
The present NMR study revealed that specific metabolites, such as Glu and mIns, were substantially decreased in case of acute alcohol exposed zebrafish brain.
American Psychological Association (APA)
Woo, Dong-Cheol& Kim, Goo-Young& Kim, Hyun-Ju& Bang, Eunjung& Rhim, Hyang-Shuk& Kim, Sang-Young…[et al.]. 2013. Metabolic Alterations of the Zebrafish Brain after Acute Alcohol Treatment by 1H Nuclear Magnetic Resonance Spectroscopy. Journal of Spectroscopy،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-512500
Modern Language Association (MLA)
Woo, Dong-Cheol…[et al.]. Metabolic Alterations of the Zebrafish Brain after Acute Alcohol Treatment by 1H Nuclear Magnetic Resonance Spectroscopy. Journal of Spectroscopy No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-512500
American Medical Association (AMA)
Woo, Dong-Cheol& Kim, Goo-Young& Kim, Hyun-Ju& Bang, Eunjung& Rhim, Hyang-Shuk& Kim, Sang-Young…[et al.]. Metabolic Alterations of the Zebrafish Brain after Acute Alcohol Treatment by 1H Nuclear Magnetic Resonance Spectroscopy. Journal of Spectroscopy. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-512500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512500