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Evaluation of Mo99 and Tc99m Productions Based on a High-Performance Cyclotron
Joint Authors
Taibi, A.
Boschi, A.
Uccelli, L.
Pupillo, G.
Vecchi, G.
Esposito, J.
Gambaccini, M.
Source
Science and Technology of Nuclear Installations
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Engineering Sciences and Information Technology
Abstract EN
Following preliminary feasibility studies which started at Legnaro National Laboratories (LNL) in 2011, the Italian National Institute for Nuclear Physics (INFN) research activities are underway aiming at the alternative, accelerator-driven, Mo99/Tc99m production routes.
One of the most promising approaches is to use 100Mo-enriched (i.e., >99%) molybdenum metallic targets, bombarded with high-beam-current, high-energy proton cyclotrons.
In order to get a comprehensive map of radionuclides expected, a detailed theoretical investigation has been carried out using the TALYS-TENDL 2012 excitation functions extended up to (p,6n), (p,p5n), and (p,2p4n) levels.
A series of quality parameters have thus been calculated both at the end of beam (EOB) and at longer times.
Results point out that accelerator-99Mo is of limited interest for a possible massive production because of the quite low specific activity with respect to reactor-99Mo.
Accelerator-Tc99m quality parameters (i.e., radionuclidic purity (RNP), isotopic purity (IP), and specific activities) calculated are instead quite close to the generator-Tc.
Calculations at 15, 20, and 25 MeV have thus been performed to assess the best operative irradiation condition for Tc99m production while minimizing both the short-lived and long-lived Tc contaminant radionuclides.
Although present in minimum quantities, Tc contaminants may indeed have an impact either on the pharmaceutical labeling procedures or on contributing to patient radiation dose during the diagnostic procedures.
American Psychological Association (APA)
Esposito, J.& Vecchi, G.& Pupillo, G.& Taibi, A.& Uccelli, L.& Boschi, A.…[et al.]. 2013. Evaluation of Mo99 and Tc99m Productions Based on a High-Performance Cyclotron. Science and Technology of Nuclear Installations،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-512540
Modern Language Association (MLA)
Esposito, J.…[et al.]. Evaluation of Mo99 and Tc99m Productions Based on a High-Performance Cyclotron. Science and Technology of Nuclear Installations No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-512540
American Medical Association (AMA)
Esposito, J.& Vecchi, G.& Pupillo, G.& Taibi, A.& Uccelli, L.& Boschi, A.…[et al.]. Evaluation of Mo99 and Tc99m Productions Based on a High-Performance Cyclotron. Science and Technology of Nuclear Installations. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-512540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512540