Vasoprotection by Dietary Supplements and Exercise : Role of TNFα Signaling
Joint Authors
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Vascular dysfunction contributes to the pathogenesis of various cardiovascular diseases.
Dietary supplements, including fish oil, dietary fibers, and various natural products, and exercise training exert vasoprotective effects.
However, the mechanisms underlying the vasoprotective benefits of dietary supplements and physical activity demand extensive investigation.
Accumulating evidence suggests that inflammatory cytokine tumor necrosis factor-alpha (TNFα) plays a pivotal role in the dysregulation of macrovascular and microvascular function.
TNFα induces vascular inflammation, monocyte adhesion to endothelial cells, vascular oxidative stress, apoptosis, and atherogenic response and participates in the regulation of thrombosis and coagulation through multiple signaling pathways involving NFκB, Sp1, activator protein 1, JNK, p38, STAT3, and so forth.
Dietary supplements and exercise training decrease TNFα production and ameliorate TNFα-mediated pathological changes in vasculature.
Thus, the inhibitory effects of dietary supplements and physical exercise on TNFα production and TNFα signaling may contribute to their vasoprotective properties.
American Psychological Association (APA)
Zhang, Hanrui& Zhang, Cuihua. 2011. Vasoprotection by Dietary Supplements and Exercise : Role of TNFα Signaling. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-512583
Modern Language Association (MLA)
Zhang, Hanrui& Zhang, Cuihua. Vasoprotection by Dietary Supplements and Exercise : Role of TNFα Signaling. Experimental Diabetes Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-512583
American Medical Association (AMA)
Zhang, Hanrui& Zhang, Cuihua. Vasoprotection by Dietary Supplements and Exercise : Role of TNFα Signaling. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-512583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512583