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Incorporating Amino Acids Composition and Functional Domains for Identifying Bacterial Toxin Proteins
Joint Authors
Chen, Yu-Ju
Huang, Chien-Hsun
Wu, Hsin-Yi
Lee, Tzong-Yi
Su, Min-Gang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aside from pathogenesis, bacterial toxins also have been used for medical purpose such as drugs for cancer and immune diseases.
Correctly identifying bacterial toxins and their types (endotoxins and exotoxins) has great impact on the cell biology study and therapy development.
However, experimental methods for bacterial toxins identification are time-consuming and labor-intensive, implying an urgent need for computational prediction.
Thus, we are motivated to develop a method for computational identification of bacterial toxins based on amino acid sequences and functional domain information.
In this study, a nonredundant dataset of 167 bacterial toxins including 77 exotoxins and 90 endotoxins is adopted to learn the predictive model by using support vector machines (SVMs).
The cross-validation evaluation shows that the SVM models trained with amino acids and dipeptides composition could yield an accuracy of 96.07% and 92.50%, respectively.
For discriminating endotoxins from exotoxins, the SVM models trained with amino acids and dipeptides composition have achieved an accuracy of 95.71% and 92.86%, respectively.
After incorporating functional domain information, the predictive performance is further improved.
The proposed method has been demonstrated to be able to more effectively identify and classify bacterial toxins than the other two features on independent dataset, which may aid in bacterial biomedical development.
American Psychological Association (APA)
Su, Min-Gang& Huang, Chien-Hsun& Lee, Tzong-Yi& Chen, Yu-Ju& Wu, Hsin-Yi. 2014. Incorporating Amino Acids Composition and Functional Domains for Identifying Bacterial Toxin Proteins. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-512587
Modern Language Association (MLA)
Su, Min-Gang…[et al.]. Incorporating Amino Acids Composition and Functional Domains for Identifying Bacterial Toxin Proteins. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-512587
American Medical Association (AMA)
Su, Min-Gang& Huang, Chien-Hsun& Lee, Tzong-Yi& Chen, Yu-Ju& Wu, Hsin-Yi. Incorporating Amino Acids Composition and Functional Domains for Identifying Bacterial Toxin Proteins. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-512587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512587