Molecular Mechanisms in Exercise-Induced Cardioprotection
Joint Authors
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-06
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases.
A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac antioxidant capacity, expression of endoplasmic reticulum stress proteins, anatomical and physiological changes in the coronary arteries, changes in nitric oxide production, adaptational changes in cardiac mitochondria, increased autophagy, and improved function of sarcolemmal and/or mitochondrial ATP-sensitive potassium channels.
It is currently unclear which of these protective mechanisms are essential for exercise-induced cardioprotection.
However, most investigations focus on sarcolemmal KATP channels, NO production, and mitochondrial changes although it is very likely that other mechanisms may also exist.
This paper discusses current information about these aforementioned topics and does not consider potentially important adaptations within blood or the autonomic nervous system.
A better understanding of the molecular basis of exercise-induced cardioprotection will help to develop better therapeutic strategies.
American Psychological Association (APA)
Golbidi, Saeid& Laher, Ismail. 2011. Molecular Mechanisms in Exercise-Induced Cardioprotection. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-512597
Modern Language Association (MLA)
Golbidi, Saeid& Laher, Ismail. Molecular Mechanisms in Exercise-Induced Cardioprotection. Cardiology Research and Practice No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-512597
American Medical Association (AMA)
Golbidi, Saeid& Laher, Ismail. Molecular Mechanisms in Exercise-Induced Cardioprotection. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-512597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512597