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Dendritic Cells : Cellular Mediators for Immunological Tolerance
Joint Authors
Ysebaert, Dirk
Chung, Chun Yuen J.
Cools, Nathalie
Berneman, Zwi N.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In general, immunological tolerance is acquired upon treatment with non-specific immunosuppressive drugs.
This indiscriminate immunosuppression of the patient often causes serious side-effects, such as opportunistic infectious diseases.
Therefore, the need for antigen-specific modulation of pathogenic immune responses is of crucial importance in the treatment of inflammatory diseases.
In this perspective, dendritic cells (DCs) can have an important immune-regulatory function, besides their notorious antigen-presenting capacity.
DCs appear to be essential for both central and peripheral tolerance.
In the thymus, DCs are involved in clonal deletion of autoreactive immature T cells by presenting self-antigens.
Additionally, tolerance is achieved by their interactions with T cells in the periphery and subsequent induction of T cell anergy, T cell deletion, and induction of regulatory T cells (Treg).
Various studies have described, modulation of DC characteristics with the purpose to induce antigen-specific tolerance in autoimmune diseases, graft-versus-host-disease (GVHD), and transplantations.
Promising results in animal models have prompted researchers to initiate first-in-men clinical trials.
The purpose of current review is to provide an overview of the role of DCs in the immunopathogenesis of autoimmunity, as well as recent concepts of dendritic cell-based therapeutic opportunities in autoimmune diseases.
American Psychological Association (APA)
Chung, Chun Yuen J.& Ysebaert, Dirk& Berneman, Zwi N.& Cools, Nathalie. 2013. Dendritic Cells : Cellular Mediators for Immunological Tolerance. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512605
Modern Language Association (MLA)
Chung, Chun Yuen J.…[et al.]. Dendritic Cells : Cellular Mediators for Immunological Tolerance. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-512605
American Medical Association (AMA)
Chung, Chun Yuen J.& Ysebaert, Dirk& Berneman, Zwi N.& Cools, Nathalie. Dendritic Cells : Cellular Mediators for Immunological Tolerance. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512605