Role of Glutathione in Cancer Progression and Chemoresistance
Joint Authors
Ricciarelli, Roberta
Pronzato, Maria Adelaide
Furfaro, Anna Lisa
Nitti, Mariapaola
Marinari, Umberto Maria
Traverso, Nicola
Domenicotti, Cinzia
Marengo, Barbara
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are involved in the etiology and progression of many human diseases including cancer.
While GSH deficiency, or a decrease in the GSH/glutathione disulphide (GSSG) ratio, leads to an increased susceptibility to oxidative stress implicated in the progression of cancer, elevated GSH levels increase the antioxidant capacity and the resistance to oxidative stress as observed in many cancer cells.
The present review highlights the role of GSH and related cytoprotective effects in the susceptibility to carcinogenesis and in the sensitivity of tumors to the cytotoxic effects of anticancer agents.
American Psychological Association (APA)
Traverso, Nicola& Ricciarelli, Roberta& Nitti, Mariapaola& Marengo, Barbara& Furfaro, Anna Lisa& Pronzato, Maria Adelaide…[et al.]. 2013. Role of Glutathione in Cancer Progression and Chemoresistance. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-512610
Modern Language Association (MLA)
Traverso, Nicola…[et al.]. Role of Glutathione in Cancer Progression and Chemoresistance. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-512610
American Medical Association (AMA)
Traverso, Nicola& Ricciarelli, Roberta& Nitti, Mariapaola& Marengo, Barbara& Furfaro, Anna Lisa& Pronzato, Maria Adelaide…[et al.]. Role of Glutathione in Cancer Progression and Chemoresistance. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-512610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512610