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Implication of DNA Methylation Profiling in Oral Epithelium for Lung Cancer Screening
Joint Authors
Yamashita, Yoshinori
Miyamoto, Kazuaki
Kimura, Masami
Nakano, Kikuo
Miyata, Yoshihiro
Okada, Morihito
Ohdan, Hideki
Harada, Hiroaki
Taniyama, Kiyomi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In lung cancer, the roles of molecular alterations in blood, sputum, bronchial brushing, and exhaled gas samples, which are relatively easy to obtain, have been evaluated for clinical availability.
This study was based on the hypothesis that similar molecular alterations occur in the lung and oral cavity because both are exposed to the same environmental or tobacco-derived carcinogens.
Because epigenetic alterations due to exposure to carcinogens are thought to play a major role in the development of lung cancer, the DNA methylation status of 11 genes in the oral epithelium was analyzed in lung cancer patients (n=16) and control individuals without lung cancer (n=32).
DNA methylation profiling revealed that GDNF, RARB, and HS3ST2 were methylated more frequently in cancer patients than in the control participants (P=0.0017, 0.0062, and 0.0193, resp.).
Combined analysesindicatedthat 6 of 16 cancer patients (37.5%), but only 1 of 32 control individuals (3.1%) showed DNA methylation in 2-3 of these 3 genes (P=0.0015).
These combined analyses showed the high specificity and positive predictive value in total and subgroup analyses.
Our data suggest that DNA methylation profiling using oral epithelium may help in the identification of individuals with a high risk of lung cancer.
American Psychological Association (APA)
Harada, Hiroaki& Miyamoto, Kazuaki& Yamashita, Yoshinori& Nakano, Kikuo& Taniyama, Kiyomi& Kimura, Masami…[et al.]. 2012. Implication of DNA Methylation Profiling in Oral Epithelium for Lung Cancer Screening. ISRN Pulmonology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-512642
Modern Language Association (MLA)
Harada, Hiroaki…[et al.]. Implication of DNA Methylation Profiling in Oral Epithelium for Lung Cancer Screening. ISRN Pulmonology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-512642
American Medical Association (AMA)
Harada, Hiroaki& Miyamoto, Kazuaki& Yamashita, Yoshinori& Nakano, Kikuo& Taniyama, Kiyomi& Kimura, Masami…[et al.]. Implication of DNA Methylation Profiling in Oral Epithelium for Lung Cancer Screening. ISRN Pulmonology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-512642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512642