Finite Volume Scheme for Double Convection-Diffusion Exchange of Solutes in Bicarbonate High-Flux Hollow-Fiber Dialyzer Therapy
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The efficiency of a high-flux dialyzer in terms of buffering and toxic solute removal largely depends on the ability to use convection-diffusion mechanism inside the membrane.
A two-dimensional transient convection-diffusion model coupled with acid-base correction term was developed.
A finite volume technique was used to discretize the model and to numerically simulate it using MATLAB software tool.
We observed that small solute concentration gradients peaked and were large enough to activate solute diffusion process in the membrane.
While CO2 concentration gradients diminished from their maxima and shifted toward the end of the membrane, HCO3- concentration gradients peaked at the same position.
Also, CO2 concentration decreased rapidly within the first 47 minutes while optimal HCO3- concentration was achieved within 30 minutes of the therapy.
Abnormally high diffusion fluxes were observed near the blood-membrane interface that increased diffusion driving force and enhanced the overall diffusive process.
While convective flux dominated total flux during the dialysis session, there was a continuous interference between convection and diffusion fluxes that call for the need to seek minimal interference between these two mechanisms.
This is critical for the effective design and operation of high-flux dialyzers.
American Psychological Association (APA)
Annan, Kodwo. 2012. Finite Volume Scheme for Double Convection-Diffusion Exchange of Solutes in Bicarbonate High-Flux Hollow-Fiber Dialyzer Therapy. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-512658
Modern Language Association (MLA)
Annan, Kodwo. Finite Volume Scheme for Double Convection-Diffusion Exchange of Solutes in Bicarbonate High-Flux Hollow-Fiber Dialyzer Therapy. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-512658
American Medical Association (AMA)
Annan, Kodwo. Finite Volume Scheme for Double Convection-Diffusion Exchange of Solutes in Bicarbonate High-Flux Hollow-Fiber Dialyzer Therapy. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-512658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512658