A Water-Soluble Polysaccharide from the Fruit Bodies of Bulgaria inquinans (Fries)‎ and Its Anti-Malarial Activity

Joint Authors

Gao, Ting-Ting
Li, Zonghong
Han, Han
Zhou, Yifa
Hao, Miao
Zhu, Jingjing
Ni, Weihua
Bi, Hongtao
Chen, Yan

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-05-03

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

A water-soluble polysaccharide (BIWS-4b) was purified from the fruit bodies of Bulgaria inquinans (Fries).

It is composed of mannose (27.2%), glucose (15.5%) and galactose (57.3%).

Its molecular weight was estimated to be 7.4 kDa (polydispersity index, Mw/Mn: 1.35).

Structural analyses indicated that BIWS-4b mainly contains (1→6)-linked, (1→5)-linked and (1→5,6)-linked β-Galf units; (1→4)-linked and non-reducing terminal β-Glcp units; and (1→2)-linked, (1→6)-linked, (1→2,6)-linked and non-reducing terminal α-Manp units.

When examined by the 4-day method and in a prophylactic assay in mice, BIWS-4b exhibited markedly suppressive activity against malaria while enhancing the activity of artesunate.

Immunological tests indicated that BIWS-4b significantly enhanced macrophage phagocytosis and splenic lymphocyte proliferation in malaria-bearing mice and normal mice.

The anti-malarial activity of BIWS-4b might be intermediated by enhancing immune competence and restoring artesunate-suppressed immune function.

Thus, BIWS-4b is a potential adjuvant of anti-malaria drugs.

American Psychological Association (APA)

Bi, Hongtao& Han, Han& Li, Zonghong& Ni, Weihua& Chen, Yan& Zhu, Jingjing…[et al.]. 2011. A Water-Soluble Polysaccharide from the Fruit Bodies of Bulgaria inquinans (Fries) and Its Anti-Malarial Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-512661

Modern Language Association (MLA)

Bi, Hongtao…[et al.]. A Water-Soluble Polysaccharide from the Fruit Bodies of Bulgaria inquinans (Fries) and Its Anti-Malarial Activity. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-512661

American Medical Association (AMA)

Bi, Hongtao& Han, Han& Li, Zonghong& Ni, Weihua& Chen, Yan& Zhu, Jingjing…[et al.]. A Water-Soluble Polysaccharide from the Fruit Bodies of Bulgaria inquinans (Fries) and Its Anti-Malarial Activity. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-512661

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-512661