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In Search of Novel Targets for Heart Disease : Myocardin and Myocardin-Related Transcriptional Cofactors
Joint Authors
Torrado, Mario
Mikhailov, Alexander T.
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Growing evidence suggests that gene-regulatory networks, which are responsible for directing cardiovascular development, are altered under stress conditions in the adult heart.
The cardiac gene regulatory network is controlled by cardioenriched transcription factors and multiple-cell-signaling inputs.
Transcriptional coactivators also participate in gene-regulatory circuits as the primary targets of both physiological and pathological signals.
Here, we focus on the recently discovered myocardin-(MYOCD) related family of transcriptional cofactors (MRTF-A and MRTF-B) which associate with the serum response transcription factor and activate the expression of a variety of target genes involved in cardiac growth and adaptation to stress via overlapping but distinct mechanisms.
We discuss the involvement of MYOCD, MRTF-A, and MRTF-B in the development of cardiac dysfunction and to what extent modulation of the expression of these factors in vivo can correlate with cardiac disease outcomes.
A close examination of the findings identifies the MYOCD-related transcriptional cofactors as putative therapeutic targets to improve cardiac function in heart failure conditions through distinct context-dependent mechanisms.
Nevertheless, we are in support of further research to better understand the precise role of individual MYOCD-related factors in cardiac function and disease, before any therapeutic intervention is to be entertained in preclinical trials.
American Psychological Association (APA)
Mikhailov, Alexander T.& Torrado, Mario. 2012. In Search of Novel Targets for Heart Disease : Myocardin and Myocardin-Related Transcriptional Cofactors. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-512693
Modern Language Association (MLA)
Mikhailov, Alexander T.& Torrado, Mario. In Search of Novel Targets for Heart Disease : Myocardin and Myocardin-Related Transcriptional Cofactors. Biochemistry Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-512693
American Medical Association (AMA)
Mikhailov, Alexander T.& Torrado, Mario. In Search of Novel Targets for Heart Disease : Myocardin and Myocardin-Related Transcriptional Cofactors. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-512693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512693