![](/images/graphics-bg.png)
Prostate-Specific Membrane Antigen-Based Therapeutics
Joint Authors
Tagawa, Scott T.
Tyrell, Lauren
Akhtar, Naveed H.
Pail, Orrin
Saran, Ankeeta
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Prostate cancer (PC) is the most common noncutaneous malignancy affecting men in the US, leading to significant morbidity and mortality.
While significant therapeutic advances have been made, available systemic therapeutic options are lacking.
Prostate-specific membrane antigen (PSMA) is a highly-restricted prostate cell-surface antigen that may be targeted.
While initial anti-PSMA monoclonal antibodies were suboptimal, the development of monoclonal antibodies such as J591 which are highly specific for the external domain of PSMA has allowed targeting of viable, intact prostate cancer cells.
Radiolabeled J591 has demonstrated accurate and selective tumor targeting, safety, and efficacy.
Ongoing studies using anti-PSMA radioimmunotherapy with 177Lu-J591 seek to improve the therapeutic profile, select optimal candidates with biomarkers, combine with chemotherapy, and prevent or delay the onset of metastatic disease for men with biochemical relapse.
Anti-PSMA monoclonal antibody-drug conjugates have also been developed with completed and ongoing early-phase clinical trials.
As PSMA is a selective antigen that is highly overexpressed in prostate cancer, anti-PSMA-based immunotherapy has also been studied and utilized in clinical trials.
American Psychological Association (APA)
Akhtar, Naveed H.& Pail, Orrin& Saran, Ankeeta& Tyrell, Lauren& Tagawa, Scott T.. 2011. Prostate-Specific Membrane Antigen-Based Therapeutics. Advances in Urology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-512705
Modern Language Association (MLA)
Akhtar, Naveed H.…[et al.]. Prostate-Specific Membrane Antigen-Based Therapeutics. Advances in Urology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-512705
American Medical Association (AMA)
Akhtar, Naveed H.& Pail, Orrin& Saran, Ankeeta& Tyrell, Lauren& Tagawa, Scott T.. Prostate-Specific Membrane Antigen-Based Therapeutics. Advances in Urology. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-512705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512705