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Immune Modulation in Primary Vaccinia virus Zoonotic Human Infections
Joint Authors
Abrahão, Jônatas Santos
Trindade, Giliane de Souza
Nogueira, Maurício Lacerda
Gomes, Juliana Assis Silva
Drumond, Betânia Paiva
Mota, Bruno Eduardo Fernandes
Corrêa-Oliveira, Rodrigo
de Araújo, Fernanda Fortes
Quinan, Bárbara Resende
da Fonseca, Flávio Guimarães
Ferreira, Jaqueline Maria Siqueira
Kroon, Erna Geessien
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In 2010, the WHO celebrated the 30th anniversary of the smallpox eradication.
Ironically, infections caused by viruses related to smallpox are being increasingly reported worldwide, including Monkeypox, Cowpox, and Vaccinia virus (VACV).
Little is known about the human immunological responses elicited during acute infections caused by orthopoxviruses.
We have followed VACV zoonotic outbreaks taking place in Brazil and analyzed cellular immune responses in patients acutely infected by VACV.
Results indicated that these patients show a biased immune modulation when compared to noninfected controls.
Amounts of B cells are low and less activated in infected patients.
Although present, T CD4+ cells are also less activated when compared to noninfected individuals, and so are monocytes/macrophages.
Similar results were obtained when Balb/C mice were experimentally infected with a VACV sample isolated during the zoonotic outbreaks.
Taking together, the data suggest that zoonotic VACVs modulate specific immune cell compartments during an acute infection in humans.
American Psychological Association (APA)
Gomes, Juliana Assis Silva& de Araújo, Fernanda Fortes& Trindade, Giliane de Souza& Quinan, Bárbara Resende& Drumond, Betânia Paiva& Ferreira, Jaqueline Maria Siqueira…[et al.]. 2011. Immune Modulation in Primary Vaccinia virus Zoonotic Human Infections. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-512732
Modern Language Association (MLA)
Gomes, Juliana Assis Silva…[et al.]. Immune Modulation in Primary Vaccinia virus Zoonotic Human Infections. Clinical and Developmental Immunology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-512732
American Medical Association (AMA)
Gomes, Juliana Assis Silva& de Araújo, Fernanda Fortes& Trindade, Giliane de Souza& Quinan, Bárbara Resende& Drumond, Betânia Paiva& Ferreira, Jaqueline Maria Siqueira…[et al.]. Immune Modulation in Primary Vaccinia virus Zoonotic Human Infections. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-512732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512732