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Multiple Recurrent Stent Thrombosis in a Patient with Coexisting Clopidogrel Resistance and Increased Anticardiolipin Antibodies : A Case Report
Joint Authors
Middlebrooks, Erik H.
Panda, Mukta
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The antiphospholipid syndrome (APS) is a common cause of both arterial and venous thrombosis.
While studies exist demonstrating the role of APS in coronary artery bypass graft failure, its role in stent thrombosis is less clearly documented.
Also, a literature search of PubMed did not reveal any articles regarding the coexistence of clopidogrel resistance and APS despite increasing awareness of resistance to clopidogrel treatment.
We present a case of a 59-year-old male having recurrent myocardial infarction after subacute restenosis of multiple drug-eluting stents despite anticoagulant therapy.
The patient had in-stent thrombosis of seven drug-eluting stents in a course of eight days.
He was subsequently found to have mild elevation of IgG anticardiolipin (aCL) antibody titers and resistance to clopidogrel.
Long-term anticoagulation with a combination of low-molecular-weight heparin, clopidogrel, and aspirin has been effective.
While the patient's aCL titer level was not elevated above the level required by the current diagnostic criteria for APS, we believe that this patient suffers from the antiphospholipid syndrome.
We will discuss some of the controversies surrounding the diagnosis of APS as well as appropriate treatment and recognition of the coexistence of APS and clopidogrel resistance in patients with stent thrombosis.
American Psychological Association (APA)
Middlebrooks, Erik H.& Panda, Mukta. 2010. Multiple Recurrent Stent Thrombosis in a Patient with Coexisting Clopidogrel Resistance and Increased Anticardiolipin Antibodies : A Case Report. Case Reports in Medicine،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-512738
Modern Language Association (MLA)
Middlebrooks, Erik H.& Panda, Mukta. Multiple Recurrent Stent Thrombosis in a Patient with Coexisting Clopidogrel Resistance and Increased Anticardiolipin Antibodies : A Case Report. Case Reports in Medicine No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-512738
American Medical Association (AMA)
Middlebrooks, Erik H.& Panda, Mukta. Multiple Recurrent Stent Thrombosis in a Patient with Coexisting Clopidogrel Resistance and Increased Anticardiolipin Antibodies : A Case Report. Case Reports in Medicine. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-512738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512738