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Time-Dependent Effect of Oral Morphine Consumption on the Development of Cytotrophoblast and Syncytiotrophoblast Cells of the Placental Layers during the Three Different Periods of Pregnancy in Wistar Rats
Joint Authors
Dehghani, Leila
Meamar, Rokhsareh
Sahraei, Hidayat
Kazemi, Masoomeh
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Previous studies have shown that morphine abuse during pregnancy cancause a delay in the development of the placenta and embryo and also bring about birth defects.
The present study investigates the effect of the duration of maternal morphine consumption during pregnancy, as well as the impacts of morphine abuse on the development of placental layers during the three different periods of pregnancy in Wistar rats.
Materials and Methodology.
Female Wistar rats have been used in the present study.
Experimental groups received morphine (0.05 mg/mL of drinking water) after one night of coupling with male rats for mating.
On 9th, 10th, and 14th days of pregnancy, pregnant animals were killed, and placentas were removed and fixed.
The cells of the placentas layers were calculated by light microscope and MOTIC and SPSS software.
Results.
The maternal surface thickness of the placenta was significantly increased, whereasthe fetal surface thickness of placenta was significantly decreased with morphine consumption with a time-dependent manner in experimental groups, compared to control groups.
Moreover, the number of trophoblast cells increased in both maternal and fetal surfaces of placenta with respect to the duration of morphine consumption which was overt in the experimental groups compared to the control groups.
Conclusion.
In general, the time-dependent effects of oral morphine consumption can inhibit the development and natural functioning of cytotrophoblast and syncytiotrophoblast cells of the placental layers.
American Psychological Association (APA)
Dehghani, Leila& Sahraei, Hidayat& Meamar, Rokhsareh& Kazemi, Masoomeh. 2013. Time-Dependent Effect of Oral Morphine Consumption on the Development of Cytotrophoblast and Syncytiotrophoblast Cells of the Placental Layers during the Three Different Periods of Pregnancy in Wistar Rats. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-512747
Modern Language Association (MLA)
Dehghani, Leila…[et al.]. Time-Dependent Effect of Oral Morphine Consumption on the Development of Cytotrophoblast and Syncytiotrophoblast Cells of the Placental Layers during the Three Different Periods of Pregnancy in Wistar Rats. Clinical and Developmental Immunology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-512747
American Medical Association (AMA)
Dehghani, Leila& Sahraei, Hidayat& Meamar, Rokhsareh& Kazemi, Masoomeh. Time-Dependent Effect of Oral Morphine Consumption on the Development of Cytotrophoblast and Syncytiotrophoblast Cells of the Placental Layers during the Three Different Periods of Pregnancy in Wistar Rats. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-512747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512747