Targeting the Neddylation Pathway to Suppress the Growth of Prostate Cancer Cells : Therapeutic Implication for the Men’s Cancer
Joint Authors
Feng, Yan
Fu, Shen
Guo, Xiaomao
Wang, Xiaofang
Ye, Dingwei
Jia, Lijun
Jeong, Lak Shin
Li, Chunjie
Liang, Yupei
Sun, Menghong
Zhao, Hu
Li, Lihui
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The neddylation pathway has been recognized as an attractive anticancer target in several malignancies, and its selective inhibitor, MLN4924, has recently advanced to clinical development.
However, the anticancer effect of this compound against prostate cancer has not been well investigated.
In this study, we demonstrated that the neddylation pathway was functional and targetable in prostate cancer cells.
Specific inhibition of this pathway with MLN4924 suppressed the proliferation and clonogenic survival of prostate cancer cells.
Mechanistically, MLN4924 treatment inhibited cullin neddylation, inactivated Cullin-RING E3 ligases (CRLs), and led to accumulation of tumor-suppressive CRLs substrates, including cell cycle inhibitors (p21, p27, and WEE1), NF-κB signaling inhibitor IκBα, and DNA replication licensing proteins (CDT1 and ORC1).
As a result, MLN4924 triggered DNA damage, G2 phase cell cycle arrest, and apoptosis.
Taken together, our results demonstrate the effectiveness of targeting the neddylation pathway with MLN4924 in suppressing the growth of prostate cancer cells, implicating a potentially new therapeutic approach for the men’s cancer.
American Psychological Association (APA)
Wang, Xiaofang& Li, Lihui& Liang, Yupei& Li, Chunjie& Zhao, Hu& Ye, Dingwei…[et al.]. 2014. Targeting the Neddylation Pathway to Suppress the Growth of Prostate Cancer Cells : Therapeutic Implication for the Men’s Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-512759
Modern Language Association (MLA)
Wang, Xiaofang…[et al.]. Targeting the Neddylation Pathway to Suppress the Growth of Prostate Cancer Cells : Therapeutic Implication for the Men’s Cancer. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-512759
American Medical Association (AMA)
Wang, Xiaofang& Li, Lihui& Liang, Yupei& Li, Chunjie& Zhao, Hu& Ye, Dingwei…[et al.]. Targeting the Neddylation Pathway to Suppress the Growth of Prostate Cancer Cells : Therapeutic Implication for the Men’s Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-512759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512759