Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease
Joint Authors
Lalonde, Daphnée
Leduc, Valérie
Poirier, Judes
Bélanger-Jasmin, Stéphanie
Domenger, Dorothée
De Beaumont, Louis
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-05
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Alzheimer's disease (AD)—the most common type of dementia among the elderly—represents one of the most challenging and urgent medical mysteries affecting our aging population.
Although dominant inherited mutation in genes involved in the amyloid metabolism can elicit familial AD, the overwhelming majority of AD cases, dubbed sporadic AD, do not display this Mendelian inheritance pattern.
Apolipoprotein E (APOE), the main lipid carrier protein in the central nervous system, is the only gene that has been robustly and consistently associated with AD risk.
The purpose of the current paper is thus to highlight the pleiotropic roles and the structure-function relationship of APOE to stimulate both the functional characterization and the identification of novel lipid homeostasis-related molecular targets involved in AD.
American Psychological Association (APA)
Leduc, Valérie& Domenger, Dorothée& De Beaumont, Louis& Lalonde, Daphnée& Bélanger-Jasmin, Stéphanie& Poirier, Judes. 2011. Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-22.
https://search.emarefa.net/detail/BIM-512766
Modern Language Association (MLA)
Leduc, Valérie…[et al.]. Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-22.
https://search.emarefa.net/detail/BIM-512766
American Medical Association (AMA)
Leduc, Valérie& Domenger, Dorothée& De Beaumont, Louis& Lalonde, Daphnée& Bélanger-Jasmin, Stéphanie& Poirier, Judes. Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-22.
https://search.emarefa.net/detail/BIM-512766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512766