Association of CHMP4B and Autophagy with Micronuclei : Implications for Cataract Formation
Joint Authors
Nezis, Ioannis P.
Stenmark, Harald
Sagona, Antonia P.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Autophagy is a mechanism of cellular self-degradation that is very important for cellular homeostasis and differentiation.
Components of the endosomal sorting complex required for transport (ESCRT) machinery are required for endosomal sorting and also for autophagy and the completion of cytokinesis.
Here we show that the ESCRT-III subunit CHMP4B not only localizes to normal cytokinetic bridges but also to chromosome bridges and micronuclei, the latter surrounded by lysosomes and autophagosomes.
Moreover, CHMP4B can be co-immunoprecipitated with chromatin.
Interestingly, a CHMP4B mutation associated with autosomal dominant posterior polar cataract abolishes the ability of CHMP4B to localize to micronuclei.
We propose that CHMP4B, through its association with chromatin, may participate in the autophagolysosomal degradation of micronuclei and other extranuclear chromatin.
This may have implications for DNA degradation during lens cell differentiation, thus potentially protecting lens cells from cataract development.
American Psychological Association (APA)
Sagona, Antonia P.& Nezis, Ioannis P.& Stenmark, Harald. 2014. Association of CHMP4B and Autophagy with Micronuclei : Implications for Cataract Formation. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-512767
Modern Language Association (MLA)
Sagona, Antonia P.…[et al.]. Association of CHMP4B and Autophagy with Micronuclei : Implications for Cataract Formation. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-512767
American Medical Association (AMA)
Sagona, Antonia P.& Nezis, Ioannis P.& Stenmark, Harald. Association of CHMP4B and Autophagy with Micronuclei : Implications for Cataract Formation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-512767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512767