The Role of Allogeneic Stem Cell Transplantation in RelapsedRefractory Hodgkin's Lymphoma Patients
Joint Authors
Kröger, Nicolaus
Kazantsev, Ilya
Klyuchnikov, Evgeny
Zabelina, Tatjana
Ayuk, Francis
Bacher, Ulrike
Zander, Axel Rolf
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite the favorable prognosis of most patients with Hodgkin's Lymphoma (HL), 15–20% of patients remain refractory to chemoradiotherapy, and 20–40% experience relapses following autologous stem cell transplantation (SCT) being used as salvage approach in this situation.
Long-term survival of only 20% was reported for patients who failed this option.
As some authors suggested the presence of a graft versus HL effect, allogeneic SCT was introduced as a further option.
Myeloablative strategies were reported to be able to achieve cure in some younger patients, but high nonrelapse mortality remains a problem.
Reduced intensity conditioning, in turn, was found to be associated with high posttransplant relapse rates.
As there is currently no standard in the management of HL patients who failed autologous SCT, we here review the literature on allogeneic stem cell transplantation in HL patients with a special focus on the outcomes and risk factors being reported in the largest studies.
American Psychological Association (APA)
Klyuchnikov, Evgeny& Bacher, Ulrike& Kröger, Nicolaus& Kazantsev, Ilya& Zabelina, Tatjana& Ayuk, Francis…[et al.]. 2010. The Role of Allogeneic Stem Cell Transplantation in RelapsedRefractory Hodgkin's Lymphoma Patients. Advances in Hematology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512784
Modern Language Association (MLA)
Klyuchnikov, Evgeny…[et al.]. The Role of Allogeneic Stem Cell Transplantation in RelapsedRefractory Hodgkin's Lymphoma Patients. Advances in Hematology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-512784
American Medical Association (AMA)
Klyuchnikov, Evgeny& Bacher, Ulrike& Kröger, Nicolaus& Kazantsev, Ilya& Zabelina, Tatjana& Ayuk, Francis…[et al.]. The Role of Allogeneic Stem Cell Transplantation in RelapsedRefractory Hodgkin's Lymphoma Patients. Advances in Hematology. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512784