ProAnti-Inflammatory Cytokine Imbalance in Postischemic Left Ventricular Remodeling
Joint Authors
Pastorelli, Marcello
Michela, Di Renzo
Auteri, Alberto
Silvia, Maffei
Puccetti, Luca
Gerarda, Pompella
Pasqui, Anna Laura
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
Cytokines play an important role in left ventricular remodeling consequent to myocardial ischemia.
The aim of this study was to correlate cytokine production and lymphocyte apoptosis to post-ischemic left ventricular remodeling in patients affected by acute myocardial infarction (AMI) undergoing primary cutaneous angioplasty (PCI).
Methods.
In 40 patients, affected by AMI and undergoing PCI, we evaluated peripheral blood mononuclear cells (PBMCs), tumor necrosis factor-alpha (TNF-α) and interleukin 10 (IL10) production and apoptosis on day 1, day 3, day 7, 1 month and 6 months after PCI.
Patients were divided into two subgroups of remodeling or not remodeling by echocardiographic criteria.
Results.
In the subgroup of remodeling patients, at each timepoint TNF-α production was increased significantly in comparison with the subgroup of not remodeling patients.
IL10 production was statistically lower in remodeling subjects than in not remodeling ones 1 and 6 months after reperfusion.
There were no differences between the two groups as regards lymphomonocyte apoptosis.
Conclusions.
We found an increased production of pro-inflammatory cytokine TNF-α and a corresponding decrease of anti-inflammatory/regulatory cytokine IL10 in remodeling patients and we concluded that this cytokine imbalance resulted in pro-inflammatory effects which might contribute to the progression of left ventricular remodeling.Erratum of “Pro/Anti-Inflammatory Cytokine Imbalance in Postischemic Left Ventricular Remodeling””dx.doi.org/10.1155/2010/723589
American Psychological Association (APA)
Pasqui, Anna Laura& Michela, Di Renzo& Silvia, Maffei& Pastorelli, Marcello& Gerarda, Pompella& Auteri, Alberto…[et al.]. 2010. ProAnti-Inflammatory Cytokine Imbalance in Postischemic Left Ventricular Remodeling. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-512788
Modern Language Association (MLA)
Pasqui, Anna Laura…[et al.]. ProAnti-Inflammatory Cytokine Imbalance in Postischemic Left Ventricular Remodeling. Mediators of Inflammation No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-512788
American Medical Association (AMA)
Pasqui, Anna Laura& Michela, Di Renzo& Silvia, Maffei& Pastorelli, Marcello& Gerarda, Pompella& Auteri, Alberto…[et al.]. ProAnti-Inflammatory Cytokine Imbalance in Postischemic Left Ventricular Remodeling. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-512788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512788