An Unusual Case of Aplastic Anemia Caused by Temozolomide

Abstract EN

Radiotherapy and concomitant/adjuvant therapy with temozolomide are a common treatment regimen for children and adults with high-grade glioma.

Although temozolomide is generally safe, it can rarely cause life-threatening complications.

Here we report a case of a 31-year-old female patient who underwent surgical resection followed by radiotherapy plus concomitant temozolomide.

She developed pancytopenia after adjuvant treatment with temozolomide.

A bone marrow aspiration and biopsy showed hypocellularity with very few erythroid and myeloid cells, consistent with aplastic anemia.

In the English literature, aplastic anemia due to temozolomide is extremely rare.