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Anti-Glutamic Acid Decarboxylase Antibody-Associated Ataxia as an Extrahepatic Autoimmune Manifestation of Hepatitis C Infection : A Case Report
Joint Authors
Mayo, Marlyn
Stüve, Olaf
Alkawadri, Rafeed
Estephan, Bachir
Awad, Amer M.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Extrahepatic immunological manifestations of hepatitis C virus (HCV) are well described.
In addition, antiglutamic acid decarboxylase (GAD) antibody-associated cerebellar ataxia is well-established entity.
However, there have been no reports in the literature of anti-GAD antibody-associated ataxia as an extrahepatic manifestation of HCV infection.
We report the case of a young woman with chronic hepatitis C virus and multiple extrahepatic autoimmune diseases including Sjögren syndrome and pernicious anemia who presented with subacute midline cerebellar syndrome and was found to have positive antiglutamic acid decarboxylase (GAD) antibody in the serum and cerebrospinal fluid.
An extensive diagnostic workup to rule out neoplastic growths was negative, suggesting the diagnosis of nonparaneoplastic antiglutamic acid decarboxylase antibody-associated cerebellar ataxia as an additional extrahepatic manifestation of hepatitis C virus infection.
The patient failed to respond to high-dose steroids and intravenous immunoglobulin.
Treatment with the monoclonal antibody rituximab stabilized the disease.
We postulate that anti-GAD associated ataxia could be an extrahepatic manifestation of HCV infection.
American Psychological Association (APA)
Awad, Amer M.& Stüve, Olaf& Mayo, Marlyn& Alkawadri, Rafeed& Estephan, Bachir. 2011. Anti-Glutamic Acid Decarboxylase Antibody-Associated Ataxia as an Extrahepatic Autoimmune Manifestation of Hepatitis C Infection : A Case Report. Case Reports in Neurological Medicine،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-512825
Modern Language Association (MLA)
Awad, Amer M.…[et al.]. Anti-Glutamic Acid Decarboxylase Antibody-Associated Ataxia as an Extrahepatic Autoimmune Manifestation of Hepatitis C Infection : A Case Report. Case Reports in Neurological Medicine No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-512825
American Medical Association (AMA)
Awad, Amer M.& Stüve, Olaf& Mayo, Marlyn& Alkawadri, Rafeed& Estephan, Bachir. Anti-Glutamic Acid Decarboxylase Antibody-Associated Ataxia as an Extrahepatic Autoimmune Manifestation of Hepatitis C Infection : A Case Report. Case Reports in Neurological Medicine. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-512825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512825