Clinicopathological Factors Affecting Survival and Recurrence after Initial Hepatectomy in Non-B Non-C Hepatocellular Carcinoma Patients with Comparison to Hepatitis B or C Virus
Joint Authors
Okuda, Yoshihiro
Mizuno, Shugo
Tanemura, Akihiro
Kishiwada, Masashi
Yamada, Tomomi
Shiraishi, Taizou
Kuriyama, Naohisa
Murata, Yasuhiro
Tabata, Masami
Isaji, Shuji
Sakurai, Hiroyuki
Azumi, Yoshinori
Usui, Masanobu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We evaluated clinicopathological factors affecting survival and recurrence after initial hepatectomy in non-B non-C (NBNC) hepatocellular carcinoma (HCC) patients with comparison to hepatitis B or C virus, paying attention to relationship between alcohol consumption and histopathological findings.
The medical records on the 201HCC patients who underwent initial hepatectomy between January 2000 and April 2013 were retrospectively reviewed.
NBNC patients had higher prevalence of hypertension (47.4%), diabetes mellitus (35.5%), alcohol consumption (>20 g/day) (61.8%), and preserved liver function than hepatitis B or C patients.
The 5-year survival rate of NBNC patients (74.1%) was significantly better than hepatitis B (49.1%) or C (65.0%) patients (NBNC versus B, P=0.031).
Among the NBNC patients, there was no relationship between alcohol consumption and clinicopathological findings including nonalcoholic fatty liver disease activity score (NAS).
However, the 5-year OS and RFS rates in the alcohol-unrelated NBNC patients tend to be better than in the alcohol-related.
By multivariate analysis, independent factors for OS in NBNC patients were Child-Pugh B/C, intrahepatic metastasis (im), and extrahepatic recurrence.
NBNC patients, who were highly associated with lifestyle-related disease and preserved liver function, had significantly better prognosis compared to hepatitis B/C patients; however, there was no association between alcohol consumption and histopathological findings.
American Psychological Association (APA)
Okuda, Yoshihiro& Mizuno, Shugo& Shiraishi, Taizou& Murata, Yasuhiro& Tanemura, Akihiro& Azumi, Yoshinori…[et al.]. 2014. Clinicopathological Factors Affecting Survival and Recurrence after Initial Hepatectomy in Non-B Non-C Hepatocellular Carcinoma Patients with Comparison to Hepatitis B or C Virus. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-512842
Modern Language Association (MLA)
Okuda, Yoshihiro…[et al.]. Clinicopathological Factors Affecting Survival and Recurrence after Initial Hepatectomy in Non-B Non-C Hepatocellular Carcinoma Patients with Comparison to Hepatitis B or C Virus. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-512842
American Medical Association (AMA)
Okuda, Yoshihiro& Mizuno, Shugo& Shiraishi, Taizou& Murata, Yasuhiro& Tanemura, Akihiro& Azumi, Yoshinori…[et al.]. Clinicopathological Factors Affecting Survival and Recurrence after Initial Hepatectomy in Non-B Non-C Hepatocellular Carcinoma Patients with Comparison to Hepatitis B or C Virus. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-512842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512842