Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis
Joint Authors
Waldum, Helge L.
Martinsen, Tom Chr.
Qvigstad, Gunnar
Fossmark, Reidar
Hauso, ⌀yvind
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused by long-term use of acid inhibiting drugs are at risk.
Gastric carcinogenesis in humans is affected by numerous factors and progresses slowly over years.
When using animal models with the possibility of intervention, a complex process can be dissected by studying the role of hypergastrinemia in carcinogenesis within a relatively short period of time.
We have reviewed findings from relevant models where gastric changes in animal models of long-term hypergastrinemia have been investigated.
In all species where long-term hypergastrinemia has been induced, there is an increased risk of gastric malignancy.
There is evidence that hypergastrinemia is a common causative factor in carcinogenesis in the oxyntic mucosa, while other cofactors may vary in the different models.
American Psychological Association (APA)
Fossmark, Reidar& Qvigstad, Gunnar& Martinsen, Tom Chr.& Hauso, ⌀yvind& Waldum, Helge L.. 2010. Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512851
Modern Language Association (MLA)
Fossmark, Reidar…[et al.]. Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-512851
American Medical Association (AMA)
Fossmark, Reidar& Qvigstad, Gunnar& Martinsen, Tom Chr.& Hauso, ⌀yvind& Waldum, Helge L.. Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512851