Intrahepatic Cholestasis in Sickle Cell Disease : A Case Report
Joint Authors
Silva-Pinto, Ana Cristina
Bassi, Sarah Cristina
Covas, Dimas Tadeu
Ribeiro, Fernanda Borges
Brunetta, Denise Menezes
Favarin de Macedo, Maria do Carmo
Prado, Benedito de Pina Almeida
De Santis, Gil Cunha
Piccolo Feliciano, Joao Victor
Angulo, Ivan de Lucena
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-21
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Intrahepatic cholestasis (SCIC) is an uncommon but potentially fatal complication of sickle cell disease (SCD), with a high death rate, observed mainly in patients with homozygous sickle cell anemia.
Herein, we describe a case of severe SCIC treated successfully with aggressive manual exchange transfusion (ET).
The patient was admitted with enlarged liver and signs of hepatic failure, such as hyperbilirubinemia and coagulopathy.
There was no evidence of viral hepatitis or biliary obstruction.
We performed several sessions of ET in order to reduce the percentage of HbS to levels inferior to 30%, which was successfully accomplished.
The patient had a complete recovery of hepatic function.
This case has shown that ET is an effective treatment of SCIC and should be introduced early on the onset of this severe complication.
American Psychological Association (APA)
Brunetta, Denise Menezes& Silva-Pinto, Ana Cristina& Favarin de Macedo, Maria do Carmo& Bassi, Sarah Cristina& Piccolo Feliciano, Joao Victor& Ribeiro, Fernanda Borges…[et al.]. 2010. Intrahepatic Cholestasis in Sickle Cell Disease : A Case Report. Anemia،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-512865
Modern Language Association (MLA)
Brunetta, Denise Menezes…[et al.]. Intrahepatic Cholestasis in Sickle Cell Disease : A Case Report. Anemia No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-512865
American Medical Association (AMA)
Brunetta, Denise Menezes& Silva-Pinto, Ana Cristina& Favarin de Macedo, Maria do Carmo& Bassi, Sarah Cristina& Piccolo Feliciano, Joao Victor& Ribeiro, Fernanda Borges…[et al.]. Intrahepatic Cholestasis in Sickle Cell Disease : A Case Report. Anemia. 2010. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-512865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512865
