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Clinical Spectrum of Propionic Acidaemia
Author
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To evaluate the clinical features, physical findings, diagnosis, and laboratory parameters of the patients with propionic acidaemia (PA).
Methods.
The records of diagnosed cases of propionic acidaemia were reviewed, retrospectively.
Results.
Twenty-six patients with PA had 133 admissions.
The majority (85%) of the patients exhibited clinical manifestations in the 1st week of life.
Regarding clinical features, lethargy, fever, poor feeding, vomiting, dehydration, muscular hypotonia, respiratory symptoms, encephalopathy, disturbance of tone and reflexes, and malnutrition were observed in 51–92% admissions.
Metabolic crises, respiratory diseases, hyperammonaemia, metabolic acidosis, hypoalbuminaemia, and hypocalcaemia were observed in 30–96% admissions.
Pancytopenia, ketonuria, hypoproteinemia, hypoglycaemia, and mildly disturbed liver enzymes were found in 12–41% admissions.
Generalised brain oedema was detected in 17% and cerebral atrophy in 25% admissions.
Gender-wise odd ratio analysis showed value of 1.9 for lethargy, 1.99 for respiratory diseases, 0.55 for anaemia, and 1.82 for hypocalcaemia.
Conclusion.
Propionic acidaemia usually presents with wide spectrum of clinical features and disturbances of laboratory parameters in early neonatal age.
It is associated with significant complications which deteriorate the patients’ quality of life.
Perhaps with early diagnosis of the disease and in time intervention, these may be preventable.
American Psychological Association (APA)
Rafique, Muhammad. 2013. Clinical Spectrum of Propionic Acidaemia. Journal of Nutrition and Metabolism،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-512893
Modern Language Association (MLA)
Rafique, Muhammad. Clinical Spectrum of Propionic Acidaemia. Journal of Nutrition and Metabolism No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-512893
American Medical Association (AMA)
Rafique, Muhammad. Clinical Spectrum of Propionic Acidaemia. Journal of Nutrition and Metabolism. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-512893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512893