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Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The mucosal surface of the female genital tract is a complex biosystem, which provides a barrier against the outside world and participates in both innate and acquired immune defense systems.
This mucosal compartment has adapted to a dynamic, non-sterile environment challenged by a variety of antigenic/inflammatory stimuli associated with sexual intercourse and endogenous vaginal microbiota.
Rapid innate immune defenses against microbial infection usually involve the recognition of invading pathogens by specific pattern-recognition receptors recently attributed to the family of Toll-like receptors (TLRs).
TLRs recognize conserved pathogen-associated molecular patterns (PAMPs) synthesized by microorganisms including bacteria, fungi, parasites, and viruses as well as endogenous ligands associated with cell damage.
Members of the TLR family, which includes 10 human TLRs identified to date, recognize distinct PAMPs produced by various bacterial, fungal, and viral pathogens.
The available literature regarding the innate immune system of the female genital tract during human reproductive processes was reviewed in order to identify studies specifically related to the expression and function of TLRs under normal as well as pathological conditions.
Increased understanding of these molecules may provide insight into site-specific immunoregulatory mechanisms in the female reproductive tract.
American Psychological Association (APA)
Nasu, Kaei& Narahara, Hisashi. 2010. Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-512897
Modern Language Association (MLA)
Nasu, Kaei& Narahara, Hisashi. Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract. Mediators of Inflammation No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-512897
American Medical Association (AMA)
Nasu, Kaei& Narahara, Hisashi. Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-512897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512897