Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies
Joint Authors
Shimizu, Tomomi
Takamori, Yasushi
Watanabe, Wataru
Sawamura, Rie
Yoshida, Hiroki
Park, Yong Kun
Takeshita, Youhei
Matsuno, Koji
Yasukawa, Ken
Kurokawa, Masahiko
Shiraki, Kimiyasu
Tsutsumi, Atsuko
Kai, Hisahiro
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ethanol extracts (AF-06, 07, and 08, 10 mg/kg) of Brazilian propolis were administered orally to cutaneously herpes simplex virus type 1 (HSV-1)-infected mice three times daily on days 0 to 6 after infection to evaluate their efficacies against HSV-1 infection and significantly limited development of herpetic skin lesions.
AF-07 and 08 significantly reduced virus titers in brain and/or skin on day 4 without toxicity, but AF-08 had no anti-HSV-1 activity in vitro.
AF-06 and 08 significantly enhanced delayed-type hypersensitivity (DTH) to inactivated HSV-1 antigen in infected mice.
Oral AF-08-administration significantly augmented interferon (IFN)-γ production by HSV-1 antigen from splenocytes of HSV-1-infected mice, while direct exposure of splenocytes of infected mice to AF-06 significantly elevated IFN-γ production in vitro.
Thus, AF-08 might have components that are active in vivo even after oral administration and those of AF-06 might be active only in vitro.
Because DTH is a major host defense for intradermal HSV-1 infection, augmentation of DTH response by AF-06 or 08, directly or indirectly, respectively, may contribute to their efficacies against HSV-1 infection.
In addition, AF-06 and 07 possibly contain anti-HSV-1 components contributing to their efficacies.
Such biological activities of Brazilian propolis may be useful to analyze its pharmacological actions.
American Psychological Association (APA)
Shimizu, Tomomi& Takeshita, Youhei& Takamori, Yasushi& Kai, Hisahiro& Sawamura, Rie& Yoshida, Hiroki…[et al.]. 2011. Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512911
Modern Language Association (MLA)
Shimizu, Tomomi…[et al.]. Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-512911
American Medical Association (AMA)
Shimizu, Tomomi& Takeshita, Youhei& Takamori, Yasushi& Kai, Hisahiro& Sawamura, Rie& Yoshida, Hiroki…[et al.]. Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512911