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The Association between EEG Abnormality and Behavioral Disorder : Developmental Delay in Phenylketonuria
Joint Authors
Zarafshan, Hadi
Karimzadeh, Parvaneh
Alaee, Mohammad Reza
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Background.
Brain defect leading to developmental delay is one of the clinical manifestations of phenylketonuria.
The aim of this study was to evaluate the association between EEG abnormality and developmental delay/behavioral disorders in phenylketonuria.
Patients and Methods.
105 phenylketonuria patients, who were diagnosed through newborn screening tests or during follow-up evaluation, were enrolled.
Patients who were seizure-free for at least six months before the study were included.
The developmental score were evaluated by the ASQ questionnaire (age-stage questionnaire) and the test of child symptom inventory-4 (CSI-4), respectively.
Results.
55 patients had a history of seizure more than 6 months before the study.
Seventy had abnormal EEG (cases) and 35 had normal EEG (controls).
There was no significant difference between mean phenylalanine levels in the abnormal and normal EEG groups at the time of diagnosis, after six months and at our evaluation.
Distribution of DQ level in the abnormal and normal EEG groups revealed a significant difference.
An abnormal EEG was associated with a higher percentage of low DQ levels.
Conclusion.
Paroxysmal epileptic discharges in PKU patients are important.
Treatment of these EEG abnormalities may affect developmental scores or may lead to correction of some behavioral disorders in patients.
American Psychological Association (APA)
Karimzadeh, Parvaneh& Alaee, Mohammad Reza& Zarafshan, Hadi. 2012. The Association between EEG Abnormality and Behavioral Disorder : Developmental Delay in Phenylketonuria. ISRN Pediatrics،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-512913
Modern Language Association (MLA)
Karimzadeh, Parvaneh…[et al.]. The Association between EEG Abnormality and Behavioral Disorder : Developmental Delay in Phenylketonuria. ISRN Pediatrics No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-512913
American Medical Association (AMA)
Karimzadeh, Parvaneh& Alaee, Mohammad Reza& Zarafshan, Hadi. The Association between EEG Abnormality and Behavioral Disorder : Developmental Delay in Phenylketonuria. ISRN Pediatrics. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-512913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512913