Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)
Joint Authors
Anderson, Ronald
Herbert, Jenny A.
Dix-Peek, Thérèse
Feldman, Charles
Dickens, Caroline
Mitchell, Timothy J.
Cockeran, Riana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip.
Exposure to CSC resulted in the significant (P<0.014–0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation.
These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.
American Psychological Association (APA)
Cockeran, Riana& Herbert, Jenny A.& Mitchell, Timothy J.& Dix-Peek, Thérèse& Dickens, Caroline& Anderson, Ronald…[et al.]. 2014. Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11). BioMed Research International،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-512925
Modern Language Association (MLA)
Cockeran, Riana…[et al.]. Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11). BioMed Research International No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-512925
American Medical Association (AMA)
Cockeran, Riana& Herbert, Jenny A.& Mitchell, Timothy J.& Dix-Peek, Thérèse& Dickens, Caroline& Anderson, Ronald…[et al.]. Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11). BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-512925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512925
