Application of Microarray-Based Comparative Genomic Hybridization in Prenatal and Postnatal Settings : Three Case Reports
Joint Authors
Bernier, Francois
Liu, Jing
Lauzon, Julie
Chernos, Judy
Lowry, R. Brian
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Microarray-based comparative genomic hybridization (array CGH) is a newly emerged molecular cytogenetic technique for rapid evaluation of the entire genome with sub-megabase resolution.
It allows for the comprehensive investigation of thousands and millions of genomic loci at once and therefore enables the efficient detection of DNA copy number variations (a.k.a, cryptic genomic imbalances).
The development and the clinical application of array CGH have revolutionized the diagnostic process in patients and has provided a clue to many unidentified or unexplained diseases which are suspected to have a genetic cause.
In this paper, we present three clinical cases in both prenatal and postnatal settings.
Among all, array CGH played a major discovery role to reveal the cryptic and/or complex nature of chromosome arrangements.
By identifying the genetic causes responsible for the clinical observation in patients, array CGH has provided accurate diagnosis and appropriate clinical management in a timely and efficient manner.
American Psychological Association (APA)
Liu, Jing& Bernier, Francois& Lauzon, Julie& Lowry, R. Brian& Chernos, Judy. 2011. Application of Microarray-Based Comparative Genomic Hybridization in Prenatal and Postnatal Settings : Three Case Reports. Genetics Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512940
Modern Language Association (MLA)
Liu, Jing…[et al.]. Application of Microarray-Based Comparative Genomic Hybridization in Prenatal and Postnatal Settings : Three Case Reports. Genetics Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-512940
American Medical Association (AMA)
Liu, Jing& Bernier, Francois& Lauzon, Julie& Lowry, R. Brian& Chernos, Judy. Application of Microarray-Based Comparative Genomic Hybridization in Prenatal and Postnatal Settings : Three Case Reports. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512940