![](/images/graphics-bg.png)
Cytotoxicity of Atriplex confertifolia
Joint Authors
Schaalje, G. Bruce
Lee, Christopher M.
Capua, Christopher J.
O'Neill, Kim L.
Hopson, Nick P.
Stewart, C. Malcolm M.
Booth, Gary M.
Johnston, G. Robert
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
The search for cancer treatment continues to be a global effort.
As part of this global effort, many natural products have been tested against cancer cell lines, mostly from tropically located plants.
This study reports that extracts of Atriplex confertifolia (Torr.
and Frem.) S.
Watson (Chenopodiaceae), a native North American plant (also known as shadscale or saltbush), has significant bioactivity against human breast cancer cell lines MCF-7, MDA-MB 435, MDA-MB 231, and HeLa cells (cervical cancer cells).
The bioactivity of A.
confertifolia extracts on these cells lines was compared to an FDA-approved cancer drug (Onxol®) and an industry-standard leukocyte control cell line.
Active portions of the extracts were found primarily in the polar fractions of the plant.
A dose-response curve of the extracts displayed significant cell death similar to Onxol®.
The plant extracts did not significantly inhibit the viability of the leukocyte cell line.
In a timed study, over 90% of cell lines MDA-MB 435 and HeLa died after 24 hours.
Cell death appears to result from apoptosis.
American Psychological Association (APA)
Capua, Christopher J.& Hopson, Nick P.& Stewart, C. Malcolm M.& Johnston, G. Robert& O'Neill, Kim L.& Schaalje, G. Bruce…[et al.]. 2010. Cytotoxicity of Atriplex confertifolia. Journal of Toxicology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-512964
Modern Language Association (MLA)
Capua, Christopher J.…[et al.]. Cytotoxicity of Atriplex confertifolia. Journal of Toxicology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-512964
American Medical Association (AMA)
Capua, Christopher J.& Hopson, Nick P.& Stewart, C. Malcolm M.& Johnston, G. Robert& O'Neill, Kim L.& Schaalje, G. Bruce…[et al.]. Cytotoxicity of Atriplex confertifolia. Journal of Toxicology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-512964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512964