Synthesis of Substituted Thieno[2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models
Joint Authors
Egamberdieva, D.
Tiezzi, A.
Elmuradov, B. Zh.
Mamadalieva, N. Z.
Bozorov, Kh. A.
Shakhidoyatov, Kh. M.
Triggiani, D.
Aisa, Haji A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
From 2-amino-3-ethoxycarbonyl-4,5-dimethyl-, -polymethylenethiophenes (1-4) were synthesized 2,3-disubstituted thieno[2,3-d]dihydropyrrolo-, tetrahydropyrido-, and tetrahydroazepino[1,2-a]pyrimidin-4-ones (5-16) for pharmacological investigations.
The 12 compounds (5-16) were individually evaluated for their antiproliferative activities on mammalian cancer cell models.
All tested compounds showed weak affection on human cervix adenocarcinoma cells (HeLa) whereas some of the tested compounds exhibited more consistent inhibition of cell growth on murine myeloma cells (P3X).
In both cases some compounds enhanced cell proliferation.
American Psychological Association (APA)
Bozorov, Kh. A.& Mamadalieva, N. Z.& Elmuradov, B. Zh.& Triggiani, D.& Egamberdieva, D.& Tiezzi, A.…[et al.]. 2012. Synthesis of Substituted Thieno[2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-512968
Modern Language Association (MLA)
Bozorov, Kh. A.…[et al.]. Synthesis of Substituted Thieno[2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models. Journal of Chemistry No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-512968
American Medical Association (AMA)
Bozorov, Kh. A.& Mamadalieva, N. Z.& Elmuradov, B. Zh.& Triggiani, D.& Egamberdieva, D.& Tiezzi, A.…[et al.]. Synthesis of Substituted Thieno[2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-512968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512968