T-Cell Costimulatory Molecules in Acute-Graft-Versus Host Disease : Therapeutic Implications
Joint Authors
Novelli, Silvana
Sierra, Jorge
Briones, Javier
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acute Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation.
Although this process is thought to consist of several phases, T-cell activation plays a critical role in the pathogenesis of acute GVHD.
To become efficient effectors, T-cells require additional costimulation after T-cell receptor signaling.
A number of molecules are involved in costimulation of T-cells such as CD28, CD40L, CD30, OX40, 4-1BB, ICOS, and LIGHT.
The system is regulated by inhibitory molecules, CTLA-4, and PD-1.
There is experimental evidence that those molecules are implicated in the pathogenesis of GHVD.
We describe how these molecules are involved in acute GVHD and how the blockade of costimulatory molecules may have potential implications for the treatment of patients with acute GVHD.
American Psychological Association (APA)
Briones, Javier& Novelli, Silvana& Sierra, Jorge. 2010. T-Cell Costimulatory Molecules in Acute-Graft-Versus Host Disease : Therapeutic Implications. Bone Marrow Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-512977
Modern Language Association (MLA)
Briones, Javier…[et al.]. T-Cell Costimulatory Molecules in Acute-Graft-Versus Host Disease : Therapeutic Implications. Bone Marrow Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-512977
American Medical Association (AMA)
Briones, Javier& Novelli, Silvana& Sierra, Jorge. T-Cell Costimulatory Molecules in Acute-Graft-Versus Host Disease : Therapeutic Implications. Bone Marrow Research. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-512977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512977