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Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cortical structures of the adult mammalian brain are characterized by a spectacular diversity of inhibitory interneurons, which use GABA as neurotransmitter.
GABAergic neurotransmission is fundamental for integrating and filtering incoming information and dictating postsynaptic neuronal spike timing, therefore providing a tight temporal code used by each neuron, or ensemble of neurons, to perform sophisticated computational operations.
However, the heterogeneity of cortical GABAergic cells is associated to equally diverse properties governing intrinsic excitability as well as strength, dynamic range, spatial extent, anatomical localization, and molecular components of inhibitory synaptic connections that they form with pyramidal neurons.
Recent studies showed that similarly to their excitatory (glutamatergic) counterparts, also inhibitory synapses can undergo activity-dependent changes in their strength.
Here, some aspects related to plasticity and modulation of adult cortical and hippocampal GABAergic synaptic transmission will be reviewed, aiming at providing a fresh perspective towards the elucidation of the role played by specific cellular elements of cortical microcircuits during both physiological and pathological operations.
American Psychological Association (APA)
Méndez, Pablo& Bacci, Alberto. 2011. Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot. Neural Plasticity،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-512985
Modern Language Association (MLA)
Méndez, Pablo& Bacci, Alberto. Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot. Neural Plasticity No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-512985
American Medical Association (AMA)
Méndez, Pablo& Bacci, Alberto. Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-512985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512985