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Biodegradable In Situ Gel-Forming Controlled Drug Delivery System Based on Thermosensitive Poly(ε-caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone) Hydrogel
Joint Authors
Mirzazadeh Tekie, Farnaz Sadat
Zohuri, Gholamhossein
Hadizadeh, Farzin
Mohajeri, Seyed Ahmad
Khodaverdi, Elham
Golmohammadian, Ali
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Traditional drug delivery systems which are based on multiple dosing regimens usually pose many disadvantages such as poor compliance of patients and drug plasma level variation.
To overcome the obstacles of traditional drug formulations, novel drug delivery system PCL-PEG-PCL hydrogels have been purposed in this study.
Copolymers were synthesized by rapid microwave-assisted and conventional synthesis methods.
Polymer characterizations were done using gel permeation chromatography and 1H-NMR.
Phase transition behavior was evaluated by inverting tube method and in vitro drug release profile was determined using naltrexone hydrochloride and vitamin B12 as drug models.
The results indicated that loaded drug structure and copolymer concentration play critical roles in release profile of drugs from these hydrogels.
This study also confirmed that synthesis of copolymer using microwave is the most effective method for synthesis of this kind of copolymer.
American Psychological Association (APA)
Khodaverdi, Elham& Golmohammadian, Ali& Mohajeri, Seyed Ahmad& Zohuri, Gholamhossein& Mirzazadeh Tekie, Farnaz Sadat& Hadizadeh, Farzin. 2012. Biodegradable In Situ Gel-Forming Controlled Drug Delivery System Based on Thermosensitive Poly(ε-caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone) Hydrogel. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-512988
Modern Language Association (MLA)
Khodaverdi, Elham…[et al.]. Biodegradable In Situ Gel-Forming Controlled Drug Delivery System Based on Thermosensitive Poly(ε-caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone) Hydrogel. ISRN Pharmaceutics No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-512988
American Medical Association (AMA)
Khodaverdi, Elham& Golmohammadian, Ali& Mohajeri, Seyed Ahmad& Zohuri, Gholamhossein& Mirzazadeh Tekie, Farnaz Sadat& Hadizadeh, Farzin. Biodegradable In Situ Gel-Forming Controlled Drug Delivery System Based on Thermosensitive Poly(ε-caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone) Hydrogel. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-512988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512988